Канал: Josh Osbourn

Hydrolysis Combo - 2024

Hydrolysis Combo - 2024

Hydration

Hydration

Organometallic Addition to Aldehydes and Ketones

Organometallic Addition to Aldehydes and Ketones

The Carbonyl as an Electrophile

The Carbonyl as an Electrophile

Preparation of Aldehydes and Ketones (231)

Preparation of Aldehydes and Ketones (231)

Common Aldehydes and Ketones (231)

Common Aldehydes and Ketones (231)

DNA and RNA (231)

DNA and RNA (231)

Heterocycles (231)

Heterocycles (231)

Amine Prep - Reduction (231)

Amine Prep - Reduction (231)

mCPBA Epoxidation (Chem 231)

mCPBA Epoxidation (Chem 231)

Choosing the Correct Reagent for the Desired Stereochemistry (Chem 231)

Choosing the Correct Reagent for the Desired Stereochemistry (Chem 231)

Conversion of an Alcohol into a Tosylate

Conversion of an Alcohol into a Tosylate

Conversion of an Alcohol to an Organohalide (Chem 231)

Conversion of an Alcohol to an Organohalide (Chem 231)

Intro to Alcohols, Ethers, Epoxides (Chem 231)

Intro to Alcohols, Ethers, Epoxides (Chem 231)

Diazonium Ion Synthesis Problems - 4

Diazonium Ion Synthesis Problems - 4

Diazonium Ion Synthesis Problems - 8

Diazonium Ion Synthesis Problems - 8

Diazonium Ion Synthesis Problems - 7

Diazonium Ion Synthesis Problems - 7

Diazonium Ion Synthesis Problems - 6

Diazonium Ion Synthesis Problems - 6

Diazonium Ion Synthesis Problems - 5

Diazonium Ion Synthesis Problems - 5

Diazonium Ion Synthesis Problems - 3

Diazonium Ion Synthesis Problems - 3

Diazonium Ion Synthesis Problems - 2

Diazonium Ion Synthesis Problems - 2

Diazonium Ion Synthesis Problems - 1

Diazonium Ion Synthesis Problems - 1

Mirror Image of Achiral Molecule

Mirror Image of Achiral Molecule

Wittig - 236 Lab.mp4

Wittig - 236 Lab.mp4

TH Ch 6 HW - Most Stable Chair.mp4

TH Ch 6 HW - Most Stable Chair.mp4

Exam 2 - F17 - Q19d Soln.mp4

Exam 2 - F17 - Q19d Soln.mp4

Exam 2 - Fall 18 - Q23 Soln.mp4

Exam 2 - Fall 18 - Q23 Soln.mp4

Exam 2 - F17 - Q27 Soln.mp4

Exam 2 - F17 - Q27 Soln.mp4

Exam 2 - F17 - Q22 Soln.mp4

Exam 2 - F17 - Q22 Soln.mp4

Exam 2 - F17 - Q19c Soln.mp4

Exam 2 - F17 - Q19c Soln.mp4

TH - Stereocenters - 3 Soln.mp4

TH - Stereocenters - 3 Soln.mp4

TH - Stereocenters - 2 Soln.mp4

TH - Stereocenters - 2 Soln.mp4

TH - Stereocenters - 1 Soln.mp4

TH - Stereocenters - 1 Soln.mp4

The Addition of Grignard and Organolithium Reagents to Esters and Acid Chlorides

The Addition of Grignard and Organolithium Reagents to Esters and Acid Chlorides

Wittig Reaction Example

Wittig Reaction Example

The Wittig Reagent

The Wittig Reagent

The Wittig Reaction

The Wittig Reaction

Hydrolysis Practice Problem

Hydrolysis Practice Problem

Enamine Hydrolysis

Enamine Hydrolysis

Imine Hydrolysis

Imine Hydrolysis

Acetal Hydrolysis

Acetal Hydrolysis

Introduction to Hydrolysis

Introduction to Hydrolysis

Addition of Secondary Amines – Enamine Formation

Addition of Secondary Amines – Enamine Formation

Addition of Primary Amines – Imine Formation

Addition of Primary Amines – Imine Formation

Protection of Aldehydes and Ketones

Protection of Aldehydes and Ketones

Intramolecular Hemiacetal Formation

Intramolecular Hemiacetal Formation

Addition of Alcohols to Aldehydes and Ketones

Addition of Alcohols to Aldehydes and Ketones

Hydration Mechanism – Base Catalyzed

Hydration Mechanism – Base Catalyzed

Hydration Mechanism – Acid Catalyzed

Hydration Mechanism – Acid Catalyzed

Hydration Mechanism – Neutral Conditions

Hydration Mechanism – Neutral Conditions

Addition of Water to Aldehydes and Ketones

Addition of Water to Aldehydes and Ketones

Assessing the Reactivity of Aldehydes and Ketones

Assessing the Reactivity of Aldehydes and Ketones

Carbonyl Reactivity Trend

Carbonyl Reactivity Trend

Nomenclature of Aldehydes and Ketones

Nomenclature of Aldehydes and Ketones

Synthesis Example 4

Synthesis Example 4

Synthesis Example 3

Synthesis Example 3

Synthesis Example 2

Synthesis Example 2

Synthesis Example 1

Synthesis Example 1

Organolithium vs Organomagnesium vs Organocuprate Addition

Organolithium vs Organomagnesium vs Organocuprate Addition

Addition of an Organocuprate to an a,b-Unsaturated Aldehyde or Ketone

Addition of an Organocuprate to an a,b-Unsaturated Aldehyde or Ketone

Addition of an Organocuprate to an Acid Chloride

Addition of an Organocuprate to an Acid Chloride

Alcohol Protecting Groups

Alcohol Protecting Groups

Addition of the Acetylide Ion to C=O

Addition of the Acetylide Ion to C=O

Retrosynthetic Analysis – Grignard and Organolithium Additions

Retrosynthetic Analysis – Grignard and Organolithium Additions

Addition of Grignard and Organolithium Reagents to Esters and Acid Chlorides

Addition of Grignard and Organolithium Reagents to Esters and Acid Chlorides

Addition of Grignard and Organolithium Reagents to Aldehydes and Ketones

Addition of Grignard and Organolithium Reagents to Aldehydes and Ketones

Introduction to Organometallic Reagents

Introduction to Organometallic Reagents

Oxidation of Alcohols and Aldehydes

Oxidation of Alcohols and Aldehydes

Chemoselective Reduction

Chemoselective Reduction

Reduction of Amides

Reduction of Amides

Reduction of Carboxylic Acids

Reduction of Carboxylic Acids

Reduction of Esters to Aldehydes

Reduction of Esters to Aldehydes

Reduction of Esters to Alcohols

Reduction of Esters to Alcohols

Reduction of Acid Chlorides

Reduction of Acid Chlorides

Comparison of Carbonyl Containing Functional Groups

Comparison of Carbonyl Containing Functional Groups

Hydride Reduction vs Hydrogenation

Hydride Reduction vs Hydrogenation

Reduction of Aldehydes and Ketones

Reduction of Aldehydes and Ketones

Epoxide Opening: Examples with Stereochemistry

Epoxide Opening: Examples with Stereochemistry

Epoxide Opening Under Basic Conditions

Epoxide Opening Under Basic Conditions

Epoxide Opening Under Acidic Conditions

Epoxide Opening Under Acidic Conditions

Intramolecular Williamson Ether Synthesis

Intramolecular Williamson Ether Synthesis

mCPBA Epoxidation

mCPBA Epoxidation

Introduction to Cyclic Ethers

Introduction to Cyclic Ethers

Reaction of Ethers with HX

Reaction of Ethers with HX

Acid Catalyzed Addition of an Alcohol to an Alkene

Acid Catalyzed Addition of an Alcohol to an Alkene

The Williamson Ether Synthesis

The Williamson Ether Synthesis

Nomenclature of Ethers

Nomenclature of Ethers

The Pinacol Rearrangement

The Pinacol Rearrangement

Dehydration of Alcohols with Acid

Dehydration of Alcohols with Acid

Dehydration of Alcohols with POCl3

Dehydration of Alcohols with POCl3

Choosing the Appropriate Reagent for the Desired Stereochemistry

Choosing the Appropriate Reagent for the Desired Stereochemistry

Conversion of an Alcohol to a Tosylate

Conversion of an Alcohol to a Tosylate

Conversion of an Alcohol to a Halogen

Conversion of an Alcohol to a Halogen

HX Addition to Alcohols

HX Addition to Alcohols

Preparation of Alcohols

Preparation of Alcohols

Physical Properties of Alcohols

Physical Properties of Alcohols

Nomenclature of Alcohols – Rings

Nomenclature of Alcohols – Rings

Nomenclature of Alcohols – Chains

Nomenclature of Alcohols – Chains

Classification of Alcohols

Classification of Alcohols

SNAr – Benzyne Mechanism

SNAr – Benzyne Mechanism

SNAr - Addition Elimination Mechanism

SNAr - Addition Elimination Mechanism

Introduction to Nucleophilic Aromatic Substitution

Introduction to Nucleophilic Aromatic Substitution

Synthesis of Substituted Benzenes II

Synthesis of Substituted Benzenes II

General Preparation of a Diazonium Ion from Benzene

General Preparation of a Diazonium Ion from Benzene

Diazonium Ion Chemistry

Diazonium Ion Chemistry

Amine Oxidation by Nitrous Acid

Amine Oxidation by Nitrous Acid

Reactions of Disubstituted Benzenes

Reactions of Disubstituted Benzenes

Synthesis of Substituted Benzenes I

Synthesis of Substituted Benzenes I

Reactions of Monosubstituted Benzenes

Reactions of Monosubstituted Benzenes

Mechanistic Analysis of Directing Group Effects – Moderate Deactivating Group

Mechanistic Analysis of Directing Group Effects – Moderate Deactivating Group

Mechanistic Analysis of Directing Group Effects – Strong Deactivating Group

Mechanistic Analysis of Directing Group Effects – Strong Deactivating Group

Mechanistic Analysis of Directing Group Effects – Strong Activating Group

Mechanistic Analysis of Directing Group Effects – Strong Activating Group

Mechanistic Analysis of Directing Group Effects – Weak Activating Group

Mechanistic Analysis of Directing Group Effects – Weak Activating Group

Mechanistic Analysis of Directing Group Effects

Mechanistic Analysis of Directing Group Effects

Why is it Important to Understand Directing Group Effects?

Why is it Important to Understand Directing Group Effects?

Opposing Group Effects

Opposing Group Effects

Resonance Effects

Resonance Effects

Inductive Effects

Inductive Effects

Reactivity Trends: Activating and Deactivating Groups

Reactivity Trends: Activating and Deactivating Groups

Substituent Effects on Reactivity

Substituent Effects on Reactivity

Reduction of the Arene Nitro Group

Reduction of the Arene Nitro Group

Aromatic Side Chain Oxidation

Aromatic Side Chain Oxidation

Benzylic Bromination

Benzylic Bromination

Reduction of Aryl Ketones

Reduction of Aryl Ketones

Friedel-Crafts Acylation

Friedel-Crafts Acylation

Features of the Friedel-Crafts Alkylation

Features of the Friedel-Crafts Alkylation

Friedel-Crafts Alkylation

Friedel-Crafts Alkylation

Sulfonation of Benzene

Sulfonation of Benzene

Nitration of Benzene

Nitration of Benzene

Halogenation of Benzene

Halogenation of Benzene

Introduction to Reactions of Benzene

Introduction to Reactions of Benzene

15.2.3 – Naming Di and Tri Substituted Benzene Rings

15.2.3 – Naming Di and Tri Substituted Benzene Rings

15.3.7 – Using Aromaticity to Predict Reactivity

15.3.7 – Using Aromaticity to Predict Reactivity

15.3.6 – Using Aromaticity to Predict Heterocycle Basicity

15.3.6 – Using Aromaticity to Predict Heterocycle Basicity

15.3.5 – Aromaticity and Lone Pairs

15.3.5 – Aromaticity and Lone Pairs

15.3.4 – Aromaticity in Heterocycles

15.3.4 – Aromaticity in Heterocycles

15.3.3 – Determining Aromaticity Examples

15.3.3 – Determining Aromaticity Examples

15.3.2 – Aromaticity and Stability

15.3.2 – Aromaticity and Stability

15.3.1 – Introduction to Aromaticity

15.3.1 – Introduction to Aromaticity

15.2.2 – Disubstituted Benzene Rings – o,m,p Terminology

15.2.2 – Disubstituted Benzene Rings – o,m,p Terminology

15.2.1 – Naming Monosubstituted Benzene Rings

15.2.1 – Naming Monosubstituted Benzene Rings

15.1.2 – The Structure of Benzene

15.1.2 – The Structure of Benzene

15.1.1 – Introduction to Aromatic Rings

15.1.1 – Introduction to Aromatic Rings

14.4.7 - Diels-Alder Retrosynthesis

14.4.7 - Diels-Alder Retrosynthesis

14.4.6 - Bicyclic Rings

14.4.6 - Bicyclic Rings

14.4.5 - Using Cyclic Dienes in the Diels-Alder Reaction

14.4.5 - Using Cyclic Dienes in the Diels-Alder Reaction

14.4.4 - Features of the Diels-Alder Reaction – The Diene

14.4.4 - Features of the Diels-Alder Reaction – The Diene

14.4.3 - Features of the Diels-Alder Reaction – The Dienophile

14.4.3 - Features of the Diels-Alder Reaction – The Dienophile

14.4.2 - Features of the Diels-Alder Reaction – Reaction Stereochemistry

14.4.2 - Features of the Diels-Alder Reaction – Reaction Stereochemistry

14.4.1 - The Diels-Alder [4+2] Cycloaddition

14.4.1 - The Diels-Alder [4+2] Cycloaddition

14.3.1 - Electron Donating and Withdrawing

14.3.1 - Electron Donating and Withdrawing

14.2.6 - Addition of X2 to a Conjugated Diene

14.2.6 - Addition of X2 to a Conjugated Diene

14.2.5 - Example: Kinetic vs Thermodynamic Products

14.2.5 - Example: Kinetic vs Thermodynamic Products

14.2.4 - Kinetic vs Thermodynamic Control of the Reaction

14.2.4 - Kinetic vs Thermodynamic Control of the Reaction

14.2.3 - Reaction of Conjugated Dienes with HX

14.2.3 - Reaction of Conjugated Dienes with HX

14.2.2 - Reactions of Isolated Dienes

14.2.2 - Reactions of Isolated Dienes

14.2.1 - Introduction to Dienes

14.2.1 - Introduction to Dienes

14.1.3 - Resonance Contributors

14.1.3 - Resonance Contributors

14.1.2 - Delocalization of Lone Pairs and Carbanions

14.1.2 - Delocalization of Lone Pairs and Carbanions

14.1.1 - Introduction to Delocalized Electrons and Resonance

14.1.1 - Introduction to Delocalized Electrons and Resonance

NMR Interpretation - 3

NMR Interpretation - 3

NMR Interpretation - 2

NMR Interpretation - 2

NMR Interpretation - 1

NMR Interpretation - 1

NMR Coupling (Condensed Version)

NMR Coupling (Condensed Version)

5.13.4 - Alternative Method for Converting a Structure to a Fischer Projection

5.13.4 - Alternative Method for Converting a Structure to a Fischer Projection

5.13.3 - Fischer Projections for Molecules with More than One Chiral Center

5.13.3 - Fischer Projections for Molecules with More than One Chiral Center

5.13.2 - Manipulating a Fischer Projection

5.13.2 - Manipulating a Fischer Projection

5.13.1 - Introduction to Fischer Projections

5.13.1 - Introduction to Fischer Projections

5.2 - Stereoisomers

5.2 - Stereoisomers

5.11.3 - Optical Activity Summary

5.11.3 - Optical Activity Summary

5.11.1 - Working With Enantiomers - Optical Activity

5.11.1 - Working With Enantiomers - Optical Activity

5.11.2 - Measuring Optical Activity

5.11.2 - Measuring Optical Activity

5.10.3 - Example 2 - What Is the Relationship

5.10.3 - Example 2 - What Is the Relationship

5.10.2 - Example 1 - Identify the Chiral Centers in a Cyclic Molecule

5.10.2 - Example 1 - Identify the Chiral Centers in a Cyclic Molecule

5.10.1 - The Stereochemistry of Cyclic Compounds

5.10.1 - The Stereochemistry of Cyclic Compounds

5.9.6 - Example 2 - What is the Relationship

5.9.6 - Example 2 - What is the Relationship

5.9.5 - Example 1d - Does the Molecule Have an Enantiomer 2

5.9.5 - Example 1d - Does the Molecule Have an Enantiomer 2

5.9.4 - Example 1c - What Is the Relationship

5.9.4 - Example 1c - What Is the Relationship

5.9.1 - Classifying Molecules as Chiral, Achiral, or Achiral-Meso

5.9.1 - Classifying Molecules as Chiral, Achiral, or Achiral-Meso

5.9.3 - Example 1b - Does the Molecule Have an Enantiomer

5.9.3 - Example 1b - Does the Molecule Have an Enantiomer

5.9.2 - Example 1a - Chiral, Achiral, or Achiral-Meso

5.9.2 - Example 1a - Chiral, Achiral, or Achiral-Meso

5.8.1 - Introduction to Diastereomers

5.8.1 - Introduction to Diastereomers

5.8.2 - Meso Compounds

5.8.2 - Meso Compounds

5.7 - Stereochemistry Recap

5.7 - Stereochemistry Recap

5.6.4 - Dealing with a Tie When Prioritizing Groups

5.6.4 - Dealing with a Tie When Prioritizing Groups

5.6.5 - R/S Assignment - Example 2

5.6.5 - R/S Assignment - Example 2

5.6.6 - Dealing with Pi Bonds When Prioritizing Groups

5.6.6 - Dealing with Pi Bonds When Prioritizing Groups

5.6.3 - R/S Assignment - Example 1

5.6.3 - R/S Assignment - Example 1

5.6.2 - Basic Steps to Make an R/S Assignment

5.6.2 - Basic Steps to Make an R/S Assignment

5.6.1 - R/S Assignment to Describe Chiral Centers

5.6.1 - R/S Assignment to Describe Chiral Centers

5.5 - Analyzing a Pair of Enantiomers

5.5 - Analyzing a Pair of Enantiomers

5.4 - Viewing a Chiral Center in 3D

5.4 - Viewing a Chiral Center in 3D

5.3 - Chirality and Asymmetric Centers

5.3 - Chirality and Asymmetric Centers

5.1 - Introduction to Stereochemistry

5.1 - Introduction to Stereochemistry

Strain In Organic Molcules

Strain In Organic Molcules

3D View of Ethane (Revised)

3D View of Ethane (Revised)

Structure Drawing Practice 6

Structure Drawing Practice 6

Structure Drawing Practice 5

Structure Drawing Practice 5

Structure Drawing Practice 4

Structure Drawing Practice 4

Structure Drawing Practice 3

Structure Drawing Practice 3