Канал: Boston Protein Design and Modeling Club

Massively parallel discovery of peptides to inhibit cellular protein interactions

Massively parallel discovery of peptides to inhibit cellular protein interactions

Small But Mighty: What an LSTM Network Reveals About Protein Design and About Machine Learning

Small But Mighty: What an LSTM Network Reveals About Protein Design and About Machine Learning

Jointly Embedding Protein Structures and Sequences through Residue Level Alignment

Jointly Embedding Protein Structures and Sequences through Residue Level Alignment

Discrete diffusion models for generative protein design

Discrete diffusion models for generative protein design

Review and discussion of AlphaFold3

Review and discussion of AlphaFold3

Recent methods for protein structure generation and design

Recent methods for protein structure generation and design

Designer proteins for stem cell engineering

Designer proteins for stem cell engineering

Shedding light on functional dark matter with genomic language modeling

Shedding light on functional dark matter with genomic language modeling

Computational Design of non-porous, pH-responsive antibody nanoparticles

Computational Design of non-porous, pH-responsive antibody nanoparticles

Unsupervised early warning of viral antibody escape to design & test variant-proof therapeutics

Unsupervised early warning of viral antibody escape to design & test variant-proof therapeutics

Bridging Biophysics and AI to Optimize Protein Design

Bridging Biophysics and AI to Optimize Protein Design

Learning transferable protein backmapping from conformational ensembles

Learning transferable protein backmapping from conformational ensembles

DiffDock: Diffusion Steps, Twists and Turns for Molecular Docking and Beyond!

DiffDock: Diffusion Steps, Twists and Turns for Molecular Docking and Beyond!

Computational design of autoinhibitory domains for a protease-activated PD-L1 antagonist

Computational design of autoinhibitory domains for a protease-activated PD-L1 antagonist

Exploring structural heterogeneity through cryoEM, cryoET, and deep learning

Exploring structural heterogeneity through cryoEM, cryoET, and deep learning

Investigating the volume &diversity of data needed for generalizable antibody-antigen ∆∆G prediction

Investigating the volume &diversity of data needed for generalizable antibody-antigen ∆∆G prediction

Exploration of novel functional sequence space using evolution-informed design

Exploration of novel functional sequence space using evolution-informed design

Understanding & discovering fold-switching proteins by combining AlphaFold2 & sequence clustering

Understanding & discovering fold-switching proteins by combining AlphaFold2 & sequence clustering

Fragment-based backbone sampling & neural net derived potentials to design protein-binding peptides

Fragment-based backbone sampling & neural net derived potentials to design protein-binding peptides

Building a global data supply chain to improve protein design and protect biodiversity

Building a global data supply chain to improve protein design and protect biodiversity

Expanding the Universe of Functional Proteins by Computational Design

Expanding the Universe of Functional Proteins by Computational Design

Protein sequence design by explicit energy landscape optimization

Protein sequence design by explicit energy landscape optimization

Designing ligand-binding proteins from scratch

Designing ligand-binding proteins from scratch

De novo design of mini-proteins to inhibit bacterial biofilm formation

De novo design of mini-proteins to inhibit bacterial biofilm formation

Tertiary motifs as building blocks for the design of protein binding peptides

Tertiary motifs as building blocks for the design of protein binding peptides

A computational approach to design structured peptides and predict peptide behavior in solution

A computational approach to design structured peptides and predict peptide behavior in solution

Designing cKIT Receptor Inhibitors to Clear Hematopoietic Stem Cells Prior to Bone Marrow Transplant

Designing cKIT Receptor Inhibitors to Clear Hematopoietic Stem Cells Prior to Bone Marrow Transplant

Initial reaction to AlphaFold2 right after CASP14

Initial reaction to AlphaFold2 right after CASP14

The 7 Habits of Highly Successful Protein Therapeutics

The 7 Habits of Highly Successful Protein Therapeutics

Massively Parallel Protein Design to Develop Enzymes for Next-Generation Chemotherapy

Massively Parallel Protein Design to Develop Enzymes for Next-Generation Chemotherapy

New tools for studying the mechanics of single proteins

New tools for studying the mechanics of single proteins

Why designs fail, and how they move

Why designs fail, and how they move

De novo Glycan Modeling and Design

De novo Glycan Modeling and Design

A view of the structure-fitness landscape from an unsupervised vantage

A view of the structure-fitness landscape from an unsupervised vantage

Rational de novo design of disulfide-rich miniprotein agonists and antagonists for family B GPCRs

Rational de novo design of disulfide-rich miniprotein agonists and antagonists for family B GPCRs

From large to small, protein design for stability and de novo interfaces

From large to small, protein design for stability and de novo interfaces

Therapeutic enzyme engineering using a generative neural network

Therapeutic enzyme engineering using a generative neural network

Learning from natural antibodies for sequence generation and fast structure prediction

Learning from natural antibodies for sequence generation and fast structure prediction

ColabDesign - Tutorial on using structure prediction methods for protein design

ColabDesign - Tutorial on using structure prediction methods for protein design

How local changes in secondary structure flexibility can drive protein function

How local changes in secondary structure flexibility can drive protein function

Learning to design mini-proteins that bind to specific protein targets

Learning to design mini-proteins that bind to specific protein targets

Predicting protein structures from single sequences

Predicting protein structures from single sequences

ColabFold - Making protein folding accessible to all via Google Colab!

ColabFold - Making protein folding accessible to all via Google Colab!