The ketogenic diet was originally studied and used in patients with seizure disorders, such as epilepsy. The ketogenic diet was shown to be superior to anticonvulsant drug therapies for seizure reduction or remission in a large portion this patient population. The underlying mechanisms mediating the profound impact of the ketogenic diet on seizure disorders include the suppression of oxidative stress and inflammation, in addition to the brain being fed ketones, which are a more efficient fuel source than glucose. In this discussion Dr. Dominic D’Agostino explores the benefits and mechanisms of the ketogenic diet in brain health, exploring conditions beyond epilepsy.
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