In this episode of The Human Upgrade, Dave Asprey sits down with Paul Saladino, M.D., a leading voice in the carnivore space, for a deep dive into the intricacies of diet evolution, holistic health, and metabolic science. Together, they unravel the challenges and adaptations that emerge when experimenting with strict diets like the carnivore diet and keto diet.
Paul shares his personal journey from a strict carnivore diet—meat, organs, and salt—to reintroducing fruit and honey after experiencing issues like electrolyte imbalances and hormonal shifts. This episode explores how dietary shifts can lead to improved metabolic health, weight loss, and overall wellness by incorporating a balance of macronutrients tailored to individual needs.
Dave and Paul discuss why diets fail for many, touching on key issues like the calorie myth, the importance of food quality, and the overlooked dangers of plant toxins such as oxalates and saponins. They also examine why traditional "healthy" foods, like oats and quinoa, may not provide the health benefits they’re often credited for.
Listeners will gain insights into the pitfalls of extreme carbohydrate restriction and the role of insulin in overall health. They’ll also explore why healthy eating should prioritize nutrient-dense foods over calorie-counting and how regenerative farming practices tie into achieving a sustainable fitness journey. Paul’s reflections dive into misconceptions surrounding nutrition, the body's need for minerals, and how ancestral practices can guide modern dietary choices.
Whether you're seeking fat loss, curious about the synergy between keto diet principles and bio-individuality, or eager to explore actionable nutrition tips, this conversation delivers transformative insights into achieving a sustainable body transformation and lifelong wellness.
Sponsors:
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Resources:
2025 Biohacking Conference – [ Ссылка ]
Shop Paul Saladino’s Products – [ Ссылка ]
Follow Paul Saladino on Instagram – [ Ссылка ]
Paul Saladino’s Book: The Carnivore Code – [ Ссылка ]
@Paulsaladinomd
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Dave Asprey’s Website – [ Ссылка ]
Dave Asprey’s Book: Smarter Not Harder – [ Ссылка ]
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Upgrade Collective: Join The Human Upgrade Podcast Live – [ Ссылка ]
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40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – [ Ссылка ]
Chapters:
00:00 Intro
00:40 Paul Saladino’s Evolution in Diet
01:21 Challenges of a Strict Carnivore Diet
03:36 Reintroducing Carbohydrates
05:32 Debunking Common Diet Myths
13:49 The Problem with Calorie Restriction
18:30 The Importance of Food Quality
24:08 The Veganism Debate
34:15 The Benefits of Organ Meats
37:27 Foot Surgery and Bone Density
39:23 Mineral Deficiency and Plant-Based Diets
40:00 The Truth About Seed Oils
41:10 Historical Studies on Seed Oils
47:26 Mechanisms and Effects of Seed Oils
52:33 Nicotine and Neuroprotection
54:12 Oleic Acid and Longevity
01:01:44 The Benefits of Animal Fats
01:02:32 Odd Chain Fatty Acids and Health
01:11:07 Cheese and Dairy Considerations
01:13:11 The Impact of Cheese on Health
01:14:03 Protein Intake and Longevity
01:14:54 Understanding mTOR and Its Effects
01:17:35 Ideal Body Fat and Metabolic Health
01:24:38 The Role of Omega Fatty Acids
01:32:46 ApoB, Insulin Sensitivity, and Longevity
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