I discuss Oxidative Stress and how N-Acetylcysteine (NAC) could be a possible COVID-19 treatment or prevention according to a double-blind clinical trial studying the benefits of NAC to reduce the effects of respiratory diseases, specifically those caused by the H1N1 virus ([ Ссылка ]). NAC has NOT been shown to prevent you from getting infected, however NAC is currently being studied to determine if it can help your body fight off COVID-19 so you're less symptomatic. The patients in the study took 600mg 2x daily of NAC. Patients who did not take NAC were 79% likely to be symptomatic when infected with H1N1, whereas patients who took the NAC supplement were only 25% likely to be symptomatic after infection.

Here is the reasoning behind the hypothesis that NAC can help prevent or treat COVID-19:

1. The spike protein of SARS-CoV-2 binds to and inhibits the ACE2 receptor/enzyme which results in accumulation of Angiotensin II (AT-II) which stimulates production of reactive oxygen species (ROS).
2. We also now get a deficiency of what ACE2 was supposed to make (AT-1,7). AT-1,7 is known to reduce the concentration of ROS.
3. COVID-19 also results in activating your immune cells, specifically Neutrophils, which cause production of more ROS (that can cause endothelial cell damage and organ failure).

Academic papers state that oxidative stress is a significant reason why people have symptoms when they are infected. The increased oxidative stress could be caused by a lack of GSH.

Great video explaining this in more detail: [ Ссылка ] (Dr. Seheult)

Citation:
Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment.
De Flora S, Grassi C, Carati L.

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