How is obesity linked to inflammation?
Proinflammatory activation of macrophages in metabolic tissues is critically important in the induction of obesity-induced inflammation. In this 2021 PNAS paper, Embgenbroich et al. demonstrate that the soluble mannose receptor (sMR) plays a direct functional role in both macrophage activation and metaflammation.
They show that sMR binds CD45 on macrophages and inhibits its phosphatase activity, leading to an Src/Akt/NF-κB–mediated cellular reprogramming toward an inflammatory phenotype both in vitro and in vivo.
Remarkably, increased serum sMR levels were observed in obese mice and humans and directly correlated with body weight and fat. Importantly, enhanced sMR levels increase serum proinflammatory cytokines, activate tissue macrophages, and promote insulin resistance.
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[ Ссылка ]00186-5.pdf
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