Barbara Eichhorst, MD, University Hospital Cologne, Cologne, Germany, briefly outlines the risk factors for Richter's transformation (RT), including complex karyotype, TP53 abberation, the metabolism in chronic lymphocytic leukemia (CLL) cells, as well as the tumor microenvironment and T-cell function. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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