Alpha-ketoglutarate (AKG) is a small compound, but plays a big role in our cells. Notably, AKG is a key component in the metabolic pathway, the Krebs Cycle. However, levels of AKG have been shown to decline with age. Delivered as a calcium salt (CaAKG), this recent publication (ref below) shows that AKG can extend healthspan in both male and female mice, and extends lifespan in middle-aged female mice. In this video, I will discuss in more detail what AKG is, the results of this paper and my thoughts.
TIMESTAMPS;
00:00 - Intro
00:56 - What is AKG? Aging connection
04:27 - Study results
08:35 - How/Why AKG has this effect?
10:00 - AKG in humans?
11:00 - Thoughts/Outlook
**reference at 3:42 should be [ Ссылка ] Aging Cell. 2020;19:e13059 !!
REFERENCES;
Paper -- Asadi Shahmirzadi et al., 2020, Cell Metabolism 32, 447–456
September 1, 2020 ª 2020 Published by Elsevier Inc.
[ Ссылка ]
Press Release - [ Ссылка ] & [ Ссылка ]
Dr Kennedy Lab; [ Ссылка ]
Extends lifespan in C.elegans; Chin, R., Fu, X., Pai, M. et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510, 397–401 (2014). [ Ссылка ]
Pigs; Oncotarget. 2017; 8:91965-91978. [ Ссылка ]
Gut Microbiome - The effects of dietary supplementation with α-ketoglutarate on the intestinal microbiota, metabolic profiles, and ammonia levels in growing pigs
[ Ссылка ]
I use Brave browser, check it out and download for free and earn BAT for browsing: [ Ссылка ]
Icons in intro; "[ Ссылка ] vector created by freepik - www.freepik.com
