Lectin Pathway

Key concepts:
1. MBL is essential in initiating the lectin pathway, it recognizes patterns of carbohydrates on pathogens
2. MASP 1 and 2 are the serine proteases. MASP-2 cleaves C2 and C4 generating C2b and C4b. .
3. C4bC2b and C4bC2bC3b are the C3 and C5 convertases of the classical and the lectin pathways, respectively.

Table of Contents:
00:10 - Function of MBL and MASP
01:04 - Formation of the C3 convertase Role of MASP 2
02:43 - Generation of C5 convertase
03:00 - Generation of MAC

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