Timothy Burns, MD, PhD, University of Pittsburgh & UPMC Hillman Cancer Center, Pittsburgh, PA, provides an overview of management strategies for patients with EGFR-mutant lung cancer that do not involve tyrosine kinase inhibitors (TKIs). Amivantamab, an EGFR-MET bispecific antibody, and lazertinib, a third-generation EGFR TKI, have been proven to be beneficial in the Phase III MARIPOSA (NCT04487080) and MARIPOSA-2 (NCT04988295) trials, where there were assessed against osimertinib and chemotherapy alone respectively. Findings from the HERTHENA-Lung01 (NCT04619004) and TROPION-Lung05 (NCT04484142) of patritumab deruxtecan and datopotamab deruxtecan were additionally discussed. This interview took place at 2024 Targeted Therapies of Lung Cancer Meeting (TTLC 2024) in Santa Monica, CA.

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