Liposome extruders are mainly used for the liposome formulation and achieving uniform size distributions. Liposome extrusion technology is employing the structural and performance characteristics of liposomal phospholipid bilayers. When the operational temperature is slightly above the phase transition temperature of phospholipids, the large vesicles of liposomes will pass through polycarbonate membranes with specific pore sizes by a certain external extrusion force. Since the pore size of polycarbonate membrane is fixed (e.g., 50nm, 100nm, 200nm, 400nm, 1um, etc.), and the polycarbonate extrusion membrane features vertical and uniform nano pore distributions on the membrane surface, when the large vesicles pass through the membrane with a specific nano pore size several times, the sample is extruded to the uniform size decided by the pore. Liposome extruders can be classified into three categories: hand driven liposome extruders, jacketed liposome extruders, and online liposome extruders. Each category is based on its different power sources. Genizer LLC helps scientists achieve desired liposome preparation by providing all three kinds of liposome extruders.

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