Objective:

Determine the significance and clinical use of  alkaline phosphatase in clinical practice


 
Lab Test Name:

Alkaline Phosphatase – ALP


 
Description:

Measures amount of ALP in circulation


Located in several places in the body:


• Liver

• Intestines

• Biliary tract

• Bones

• Placenta


Different isoenzymes of ALP are used to determine:


• Liver, bone, intestine and other cancers

• Bone turnover in postmenopausal women


 
Indications:

Evaluation of ALP:


• Hepatobiliary disease

• Malignancies

• Bone disease

• Bone damage in renal patients


 
Normal Therapeutic Values:

Normal – 40-130 U/L


Collection:


•  Plasma separator tube


 
What would cause increased levels?

Increased levels assessed in:


• Liver disease

• Bone disease

• Pregnancy

• Amyloidosis

• Lung cancer

• Pancreatic cancer

• Congestive heart failure

• Ulcerative colitis

• Hodgkin’s disease

• Chronic renal failure

• Sarcoidosis


 
What would cause decreased levels?

• Hypophosphatasia (spelling error on existing outline on NURSING.com)

• Anemia

• Kwashiorkor

• Cretinism

• Hypothyroidism

• Zinc or magnesium deficiency

• Scurvy

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