The liver plays a central role in orchestrating systemic metabolism in homeostasis and inflammation. In their Immunity study, Bergthaler and colleagues found that the antiviral cytokine type I interferon (IFN-I) is a master regulator of metabolic pathways in the liver during viral infection. Specifically, they revealed that IFN-I signaling disrupts the urea cycle and alters the metabolic output of the liver. This results in altered serum metabolite concentrations, which modulate adaptive immunity and reduce liver pathology. This study contributes to the field of systemic immunometabolism and identifies IFN-I mediated reprogramming of liver metabolism as an endogenous mechanism of immunoregulation. Credit: CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences. Check out the paper at [ Ссылка ]30458-3.
A. Lercher, A. Bhattacharya, A.M. Popa, M. Caldera, M.F. Schlapansky, H. Baazim, B. Agerer, B. Gürtl, L. Kosack, P. Májek, et al. (2019). Type 1 Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. Immunity 51.
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