In 1992, Konami released a coin-operated arcade game based on the series titled Wild West C.O.W.-Boys of Moo Mesa. The game is a side-scrolling "run 'n gun" action game similar to Konami's previous wild west-themed game Sunset Riders. Ryan Brown worked closely with Konami on the game's development.

The player characters in the game are Cowlorado Kid, Dakota Dude, Marshall Moo Montana, and Buffalo Bull. The game can be configured to allow up to four players to play simultaneously.

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