Leukemia is the 2nd leading blood cancer with approximately 60.000 new cases identified in 2020. It has different subtypes based on its origin. The most common type in adults is the chronic lymphocytic leukemia which is the result of uncontrolled proliferation of the B cells that are one kind of white blood cells. It has very diverse biological and clinical background which determines the stage of the disease. One of the most interesting stage is known as spontaneous regression which is the disappearance of the tumor overtime with or without any treatment.
Since the spontaneous regression is not a common feature of the cancer cells, it's an unclear process and needs to be addressed in order to make it possible to trigger this mechanism in other types of cancer. For this, we need to determine well established therapeutic targets which are the biological molecules that have a specific role in disease progression and can be manipulated with external forces. That's why, in this project, I investigated the mechanism behind this process in order to understand the cell’s decision by comparing the spontaneous regression and the progressive tumor state.
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