The city is well known in Morocco and throughout the Islamic world as a spiritual capital for it was home for many of the pillars of Sufism. It has been known also as "Dar Dmana" ("House of Safety") due to its containing the tomb of the 18th-century Idrisi Sharif.[2]

Many Jews of Morocco consider Ouazzane to be a holy city and make pilgrimages there to venerate the tomb of several marabouts (Moroccan saints), particularly moul Anrhaz, the local name for Rabbi Amram ben Diwan, an eighteenth-century rabbi who lived in the city and whose burial site is associated with a number of miracles.

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