Leptin is secreted by fat cells in proportion to energy stores to induce satiety at the level of the hypothalamus. Subscribe to Nourishable at [ Ссылка ]

This video is part 9 of the Neurobiology of Food Intake module within a lecture series on the nutrition science of macronutrients.

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The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only.

References
Klockars, A. et al. Hypothalamic Integration of the Endocrine Signaling Related to Food Intake. Curr. Topics Behav. Neurosci. (2019) 43:239-270

Images
Figures created with BioRender

Leptin is a reflection of the energy stores in our body. Leptin is secreted by fat cells called adipocytes in proportion to adipose tissue mass. More adipose tissue mass, more leptin is secreted. Leptin crosses the blood-brain-barrier at the arcuate nucleus of the hypothalamus to stimulate the POMC neurons to release the neurotransmitter alpha MSH. Alpha MSH in turn stimulates the MC4R receptors of the paraventricular hypothalamus to induce satiety. Leptin also inhibits the orexigenic AgRP neurons. With obesity, leptin resistance can develop. Although a high amount of leptin being secreted, however this leptin is less effective at inducing satiety due to some downstream problems in signaling of the leptin receptor in the hypothalamic neurons.

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