As new formulations of botulinum toxin type A become commercially available, generating data on the clinical comparability between products is important. In this study, Sachin M. Shridharani, MD, FACS @luxurgery and his co-author Grace Tisch, BA compared the onset of action of prabotulinumtoxinA (Pra-B) and onabotulinumtoxin (Ona-B) in the treatment of forehead and lateral canthal rhytids. A randomized, controlled, split-face pilot study was conducted with mild to severe forehead and lateral canthal rhytids. All subjects were administered Pra-B and Ona-B injections in a randomized, split-face manner.
Preliminary results from this pilot study suggest comparable time of onset and efficacy when treating the frontal and orbicularis oculi with onabotulinumtoxinA and prabotulinumtoxinA injection with a trend towards earlier onset of action for prabotulinumtoxinA.
𝐀 𝐑𝐚𝐧𝐝𝐨𝐦𝐢𝐳𝐞𝐝, 𝐂𝐨𝐧𝐭𝐫𝐨𝐥𝐥𝐞𝐝, 𝐒𝐩𝐥𝐢𝐭-𝐅𝐚𝐜𝐞 𝐒𝐭𝐮𝐝𝐲 𝐂𝐨𝐦𝐩𝐚𝐫𝐢𝐧𝐠 𝐓𝐡𝐞 𝐎𝐧𝐬𝐞𝐭 𝐎𝐟 𝐀𝐜𝐭𝐢𝐨𝐧 𝐎𝐟 𝐏𝐫𝐚𝐛𝐨𝐭𝐮𝐥𝐢𝐧𝐮𝐦𝐭𝐨𝐱𝐢𝐧-𝐀 𝐀𝐧𝐝 𝐎𝐧𝐚𝐛𝐨𝐭𝐮𝐥𝐢𝐧𝐮𝐦𝐭𝐨𝐱𝐢𝐧-𝐀
Sachin M. Shridharani, MD, FACS @luxurgery ; Co-Author: Grace Tisch, BA
Board-Certified Plastic Surgeon, Owner and Founder of LUXURGERY
DOI: 10.1097/01.GOX.0000667400.87201.7d.
