Otto and Gru find each other with the stone but are cornered by the Vicious 5, who in turn are confronted by the Anti-Villain League. However, after the clock strikes midnight, the Vicious 5 use the stone to turn themselves into animals (Belle Bottom as a dragon, Jean Clawed as a baboon, Nunchuck as a cobra, Svengeance as a tiger, and Stronghold as a bull) from the Zodiac, and kidnap Gru, planning to kill him as revenge. Kevin, Stuart, and Bob manage to find Gru, but are turned into weak animals. Wild Knuckles returns and fights the dragon Bottom. While the Minions manage to defeat most of the Vicious 5, Knuckles is badly burnt by Belle when trying to take the stone back, but Otto manages to save Gru, who uses the stone to turn the Vicious 5 into rats. The Vicious 5 are arrested, including Wild Knuckles, who is taken to a hospital where he succumbs to his injuries off screen.

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