What are NSAIDs? | Non-Steroidal Anti-inflammatory drugs mechanism of action

Inflammation is a normal , protective response to tissue injury caused by physical trauma, noxious chemicals, or microbiological agents.
Inflammation is the body's effort to inactivate or destroy invading organisms remove irritants and set the stage for tissue repair.
Non - Steroidal Anti-inflammatory drugs (NSAIDs) are a group of chemically dissimilar agents that differ in their antipyretic , analgesics and anti-inflammatory activities.
All NSAIDs act primarily by inhibiting the cyclooxygenase enzymes .
Aspirin is the prototype of this group, it is the most commonly used and the drug to which all other anti-inflammatory agents are compared..
cyclooxygenase enzymes release a substance called Prostaglandins , which causes the inflammation and they are also called the pain mediators.
When any tissue injury occur then phospholipase enzyme is released , which then convert into Arachidonic acid
Now this Arachidonic acid is the substrate for two different type of enzymes. 5- Lox and Cox enzymes.
Cyclooxygenase enzymes are responsible for the production of prostaglandins.
so.
NSAIDS work by inhibiting this COX enzymes so their will be no production of prostaglandins .

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