It wasn’t that long ago when I was sitting in lectures as a first-year psychiatry resident. We learned about the first- and second-generation antipsychotic medications in detail. One commandment that was always preached in my training was to never combine two antipsychotic medications because there is no additional benefit. Today we are here to explore this idea and see if there is truly no additional benefit to using two antipsychotics and explore why there is so much antipsychotic polypharmacy in serious mental illness. 

Time stamps
Introduction: 00:00 to 03:06
How do we know when polypharmacy should be used: 03:07 to 05:42
Using receptor binding profiles to guide decisions: 05:43 to 07:28
Combining antipsychotics for Agitation: 07:29 to 09:40
When Clozapine Does Not result in remission: 09:41 to 12:04
On LAI but it stops working before the next injection: 12:05 to 13:47
Psychosis With Insomnia: 13:48 to 15:29
Treatment for side effects: 15:30 to 16:51
You Reach a Sweet spot when switching medications: 16:52 to 18:45
Conclusion: 18:46 to 19:55

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