The innate immunity onsets with natural pathogen recognition mediated by PRRs (Pattern Recognition Receptors) followed by cellular activation and early and efficient production of pro-inflammatory cytokines. The PRRs-mediated mutual activation of cells at different tissue level, epithelial and endothelial cells and sentinel cells, resident macrophages, DC and mast cells, triggers the inflammatory response with production of “classical proinflammatory cytokines and chemokines” (IL-1, TNFα, IL-8, IL-6, MCP1) necessary for the recruitment and activation of the cellular effectors of innate immune response.
