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Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS) - a 2 minute Preview of the Experimental Protocol
Matthew Zimmerman, Landry Blanc, Pei-Yu Chen, Véronique Dartois, Brendan Prideaux
Rutgers, The State University of New Jersey, Public Health Research Institute, New Jersey Medical School;
Here, we describe a protocol using laser capture microdissection coupled with LC/MS analysis to spatially-quantify drug distributions within pulmonary tuberculosis granulomas. The approach has broad applicability to quantifying drug concentrations within tissues at high spatial detail.
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