Hemostatic Disorders can be acquired or inherited. This Pathology V-Learning™ highlights the normal hemostatic mechanism initially which includes the explanation of Blood clotting mechanism. After that, causes of bleeding, extravascular and vascular dysfunction are discussed. Alongside, light is shed on hereditary hemorrhagic telangiectasia and allergic purpura.
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Lecture Duration - 00:42:52
Release Date - January 2020
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Hemostasis is the natural process in which Blood flow slows and clot forms to prevent Blood loss during an injury. The Hemostasis and Blood Coagulation mechanism is maintained by activating primary hemostasis and secondary hemostasis pathways. The major component of hemostasis includes the vasoconstriction, platelet activation, Coagulation cascade, antithrombotic control mechanism, and fibrinolysis.
Hemostatic disorders occur in all pathways of hemostasis and can be inherited or acquired. They are usually recognized clinically by excessive Hemorrhage. Principal causes of bleeding are vascular disorders, platelet abnormalities, and Coagulation factor deficiencies.
The extravascular dysfunction due to hemostatic disorders causes senile purpura, purpura simplex, and scurvy. Vascular dysfunction is characterized into Amyloidosis, paraproteinemia, and arteritides.
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Hereditary hemorrhagic telangiectasia is another vascular malformation syndrome which is also known as Rendu-Osler-Weber syndrome. The Pathogenesis of hereditary hemorrhagic telangiectasia describes that it is an autosomal dominant disorder occurring due to Mutations in the two genes of transforming growth factor-beta (TGF-β) signaling pathway. This disorder results in arteriovenous malformation and telangiectasias. Along with this, some other clinical features of this disease are Anemia, Gastrointestinal Bleeding, dilations in Aneurysm.
Furthermore, allergic purpura is discussed. It is also known as Henoch-Schönlein Purpura. Allergic purpura is a vascular disease that results from immunologic damage to Blood vessel walls of skin, GI tract, kidney, and Joints. It is characterized by purpuric skin lesions on extensor arms and legs and buttocks.
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