A guide on how to farm Sanctum. This was my primary farming strategy for the majority of Necropolis league.
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Common Boons I like to get:
Ornate Dagger (You and your minions deal 50% more Damage)
Rusted Chimes (Gain +30 Inspiration when you gain an Affliction)
Scrying Crystal (You can see an additional room ahead on the Sanctum Map)

Common Afflictions I try to avoid:
Golden Smoke (Rewards are unknown on the Sanctum Map)
Accursed Prism (When you gain an Affliction, gain an additional random Minor Affliction)
Deceptive Mirror (You are not always taken to the room you select)

Popular builds I've seen others use to farm Sanctum:
Hexblast Mines Trickster
Shockwave Totem Hierophant

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