Florian Märkl, Ludwig-Maximilians-Universität München, Munich, Germany, discusses various approaches to utilizing chemokines to enhance cancer immunotherapy. This includes inhibition of pro-tumorigenic chemokines and increasing the abundance of anti-tumorigenic chemokines. Additionally, the overexpression of chemokine receptors on CAR-T cells may be used to improve CAR-T cell infiltration into the tumor site. These strategies utilizing and targeting chemokines are being explored for the development of novel drugs. Anti-tumorigenic chemokines in combination with oncolytic viruses and cancer vaccines have demonstrated encouraging results. This interview took place at the Immunotherapy of Cancer (ITOC) Conference 2022 in Munich, Germany.
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