Let's face it: you're getting old, but there's a reason—or, rather, there's nine. This episode is all about the hallmarks of aging, the microscopic conspirators inside your body that are plotting to slowly take away your health.
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Stock contents: Shutterstock, Videoblocks
Music:
Intro jingle courtesy of Kevin MacLeod - Incompetech.com
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Sources:
The Hallmarks of Aging:
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.
(Available for free here: [ Ссылка ]00645-4)
Oncogenes can be flipped on epigenetically: [ Ссылка ]
Senescent cells and wound healing:
[ Ссылка ]
Insulin resistance in human aging:
Chen, M., Bergman, R. N., Pacini, G., & Porte Jr, D. (1985). Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased β-cell function. The Journal of Clinical Endocrinology & Metabolism, 60(1), 13-20.
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#Aging #Biology #HallmarksOfAging #Science #LifeExtension #Telomeres #Mitochondria #Epigenetics #DNADamage #CellularSenescence #NutrientSensing #Inflammation #StemCells #Proteins #Proteostasis
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