💡 Ever wondered what makes Type 1 Diabetes tick at its core? In this episode, we take a deep dive into the fascinating world of beta cells—the tiny but mighty insulin producers in your pancreas. Learn how these cells work, why they’re vulnerable to autoimmune attack, and what cutting-edge research is revealing about beta cell regeneration and protection.
🔥 We’ll explore critical topics like:
- How beta cells regulate blood sugar and secrete insulin.
- Why beta cells are uniquely prone to damage from inflammation, oxidative stress, and misfolded proteins.
- The role of environmental triggers, including viruses, poor diet, and stress, in T1D development.
- Breakthroughs in beta cell regeneration and therapies aimed at restoring insulin production.
- How hormones like amylin and GABA contribute to glucose control and appetite regulation.
🎧 Whether you’re newly diagnosed, living with T1D, or a curious science lover, this episode will help you understand the root cause of Type 1 Diabetes and what you can do to support your beta cell health.
📚Buy my eBook documenting my dive into the iron overload-diabetes connection: [ Ссылка ]
💊 Interested in the supplements I use?
Thorne Research: [ Ссылка ]
MitoLife: [ Ссылка ]
Ancient Bliss: [ Ссылка ]
Additional resources (nutrition guide, supplement guide, exercise) [ Ссылка ]
Citations:
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2. Ashcroft, F. M., & Rorsman, P. (2012). Diabetes mellitus and the beta cell: The last ten years. Cell, 148(6), 1160-1171.
3. DeFronzo, R. A. (2009). From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58(4), 773-795.
4. Oram, R. A., & Hattersley, A. T. (2013). Genetic etiology of beta-cell dysfunction. Diabetes, 62(7), 2129-2135.
5. Lenzen, S. (2022). The pancreatic beta cell: An intricate relation between anatomical structure, the signaling mechanism of glucose-induced insulin secretion, the low antioxidative defense, and the high vulnerability to diabetic stress. Diabetes.
6. Cnop, M., Welsh, N., Jonas, J. C., Jörns, A., Lenzen, S., & Eizirik, D. L. (2005). Mechanisms of pancreatic beta-cell death in Type 1 and Type 2 diabetes: Many differences, few similarities. Diabetes, 54(Suppl 2), S97-S107.
7. Eizirik, D. L., & Mandrup-Poulsen, T. (2001). A choice of death—The signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia, 44(12), 2115-2133.
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9. von Herrath, M., & Sanda, S. (2008). The role of viruses in type 1 diabetes: A difficult dilemma. Clinical Immunology, 128(1), 1-9.
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12. Young, A. (2005). Amylin's physiology and its role in diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity, 12(2), 175-179.
13. Gilon, P., Chae, H. Y., Rutter, G. A., & Rorsman, P. (2014). Calcium signaling in pancreatic beta-cells in health and disease. Cell Calcium, 55(5-6), 331-346.
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15. Yoon, K. H., & Ko, S. H. (2006). Cellular plasticity in the pancreas and its relevance to beta-cell regeneration in diabetes. Hormone Research in Paediatrics, 65(2), 81-89.
16. Hober, D., & Sauter, P. (2010). Pathogenesis of type 1 diabetes mellitus: Interplay between enterovirus and host. Nature Reviews Endocrinology, 6(5), 279-289.
17. Vaarala, O. (2008). Gut-associated lymphoid tissue in the pathogenesis of type 1 diabetes. Frontiers in Bioscience, 13, 5364-5374.
18. Norris, J. M., & Scott, F. W. (2008). A meta-analysis of diet and insulin-dependent diabetes in humans. Pediatrics, 118(5), e1528-e1535.
19. Fineman, M. S., Shen, L. Z., & Taylor, K. (2004). Pramlintide, an amylin analog, reduces postprandial glucose excursions, inhibits glucagon secretion, and suppresses appetite in patients with diabetes. Diabetes Care, 27(3), 539-545.
20. Lutz, T. A. (2010). The role of amylin in the control of energy homeostasis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 298(6), R1475-R1484.
