What are immune checkpoints?

Immune checkpoints are receptors on the surface of T cells that can inhibit T cell activity.

Some cancer cells trick T cells by displaying ligands that interact with immune checkpoints. This is like stepping on the breaks of the T cell telling it to stop. This allows the cancer cell to avoid destruction. Immune checkpoint inhibitors such as monoclonal antibody drugs targeting PD-1 can block the interaction between immune checkpoints and their ligand to release the T-cell breaks, enabling it to destroy the cancer cell. These drugs have revolutionised cancer therapy with many new targets emerging from the lab to the clinic.

Find out more or select your immune checkpoint bioassays at: [ Ссылка ]

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