Will this crystallization process meet crystal purity development requirements? What conditions during crystallization can we change to improve our purity?
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Researchers from the world's top pharmaceutical and chemical companies use crystallization workstations to understand their crystallizations and quickly make informed decisions to determine the direction of development. In a recent study, ParticleView with PVM (a Particle Vision and Measurement tool) was used to quickly identify the exact solvent and seeding parameters that produced the desired crystal morphology, minimized agglomeration, and delivered the desired purity.

In a separate study, in only two experiments, PVM was used to pinpoint how and when an impurity was formed. This meant a robust crystallization was developed that avoided a phase separation. By providing immediate visual understanding, a crystallization workstation, coupled with PVM, enabled scientists to make informed decisions that improved crystal purity.
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GlaxoSmithKline, University College Dublin (UCD), and Sintef understand crystallization by using inline microscopy, a method proven as faster than any other.

Scientists can now directly observe key crystallization mechanisms using this method, such as:
• Crystal Purity
• Crystal Growth
• Secondary Nucleation
• Polymorphism
• Oiling Out
• Seed Aggregation

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