This is the talk by Prof. Peter Gennemark (Linköping University & AstraZeneca, Sweden) under the interdisciplinary seminar series "Molecular Communication Outside the Box: Breaking Disciplinary Boundaries" of IEEE ComSoc's Technical Committee on MBMC.
Abstract: This presentation discusses the utility of advanced in vitro systems in combination with mathematical modelling for predicting human biology, pharmacokinetics and pharmacodynamics. The talk is structured into three parts. First, I will outline a traditional drug discovery workflow, detailing the generation of preclinical in vitro and in vivo data and their integration through mathematical modelling to forecast the human scenario. Second, I will introduce microphysiological systems (MPS), currently one of the most advanced in vitro models. By combining cultures of human organ-specific cells within a microfluidic platform, these in vitro systems offer greater physiological relevance compared to standard cell cultures. Lastly, I will discuss the integration of mathematical modelling to comprehend the MPS system, its interaction with drugs, and its translation to human.
Biography: Peter Gennemark received the M.Sc. degree in engineering biology from Linköping University in 2000, and the Ph.D. degree in computing science from the Chalmers University of Technology in 2005. He is a Senior Principal Scientist in the area of drug metabolism and pharmacokinetics at AstraZeneca, Gothenburg, Sweden, and an Adjunct Associate Professor with the Department of Biomedical Engineering, Linköping University, Linköping, Sweden. He currently works with preclinical drug discovery in the cardiovascular, renal, and metabolism areas at AstraZeneca.
00:00 Intro
01:36 Overview
02:57 Traditional Drug Discovery Workflow
16:30 Microphysiological Systems (MPS)
24:59 Mathematical Modelling of MPS
38:24 Summary
40:30 Questions & Answers
Molecular Communication Outside the Box: Breaking Disciplinary Boundaries - YouTube Playlist:
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IEEE ComSoc's Technical Committee on MBMC website: [ Ссылка ]
IEEE ComSoc's Technical Committee on MBMC on LinkedIn: [ Ссылка ]
