Yoshiaki Nakamura, MD, PhD, from the National Cancer Center Hospital East, Kashiwa, Japan, discusses the significance of the tucatinib and trastuzumab combination as a chemotherapy-free treatment option for HER2-positive metastatic biliary tract cancer (BTC). Dr Nakamura highlights how previous treatment options offered limited benefits, with modest response rates and short overall-survival (OS). The results of the Phase II SGNTUC-019 trial (NCT04579380) evaluating the combination of tucatinib and trastuzumab demonstrated superior efficacy compared to historical controls, emphasizing the importance of targeted therapy over chemotherapy for patients with HER2-positive metastatic BTC. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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