Ivermectin, a potential anticancer drug derived from an antiparasitic drug
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Mechanisms of action
IVM induces different programmed cell death patterns in different tumor cells,
the main form of IVM induced programmed cell death is apoptosis.
Apoptosis
Programmed cell death
Autophagy
Lysosomal-dependent form of programmed cell death.
Pyroptosis
Inflammatory cell death induced by inflammasomes.
Kathleen T Ruddy, MD
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Forms of cancer
Breast cancer
A malignant tumor produced by gene mutation in breast epithelial cells
Digestive system cancer
Gastric cancer is one of the most common malignant tumors worldwide.
Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide.
Urinary system cancer
Renal cell carcinoma is a fatal malignant tumor of the urinary system derived from renal tubular epithelial cells.
Prostate cancer is a malignant tumor derived from prostate epithelial cells
Hematological cancer
Leukemia is a type of malignant clonal disease caused by abnormal hematopoietic stem cells
Reproductive system cancer
Cervical cancer is one of the most common gynecological malignancies
Ovarian cancer is a malignant cancer that lacks early clinical symptoms and has a poor therapeutic response.
Brain glioma
Glioma is the most common cerebral tumor
Glioblastoma, median survival time of 14-17 months
Respiratory system cancer
Nasopharyngeal carcinoma is a malignant tumor derived from epithelial cells of the nasopharyngeal mucosa.
Lung cancer has the highest morbidity and mortality among cancers
Melanoma
The most common malignant skin tumor with a high mortality rate.
Other papers
Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
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Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
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Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
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Abstract 2320: Ivermectin suppresses pancreatic cancer via mitochondria dysfunction
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Video reviews
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