For months, developed economies have hoarded Covid-19 vaccines and the raw materials needed to make them. Now, they’re being forced to act as an explosive outbreak in India raises the risk of new virus mutations that could threaten the wider world.

Under mounting criticism for dominating vaccine resources, the U.S. said this week that it will help India by sending items needed to manufacture vaccines as part of an aid package. European countries are also pledging help as new cases in the South Asian country smash world records. President Joe Biden’s administration is separately vowing to share its stockpile of AstraZeneca Plc vaccines -- which the U.S. hasn’t even approved for use -- and meeting with drug companies about boosting supply and waiving intellectual property protections on Covid-19 shots, a shift India and South Africa have been pushing for.

The moves show a growing realization that the vaccine nationalism many wealthy nations have embraced has the potential to backfire, prolonging the global pandemic. While those countries have been cornering supplies of the first vaccines for their world-leading rollouts, places like India have run short, allowing the virus to run wild. Some scientists have linked the nation of 1.3 billion people’s second wave to a more virulent strain, with the out-of-control outbreak providing a petri dish for further mutations to evolve that could challenge the vaccines now being distributed from the U.K. to Israel.

“There is certainly potential for new variants to emerge in a country the size of India that could pose a threat elsewhere,” said Ramanan Laxminarayan, founder of the New Delhi and Washington-based Center for Disease Dynamics, Economics & Policy. “It is in the world’s interest to ensure that India exits the pandemic at the earliest, and vaccination is the only way.”

While viruses undergo changes all the time, not all are significant. But some new strains in other parts of the world have ignited concerns because they could be more contagious. Earlier this year, data showed that AstraZeneca’s vaccine was less effective against one variant that emerged in South Africa.

India’s variant -- a strain named B.1.617 -- is already raising alarms. It has two critical mutations that make it more likely to transmit and escape prior immunity that has been built up, Anurag Agrawal, the director of India’s Council of Scientific and Industrial Research’s genomics institute, told Bloomberg last week.

Rakesh Mishra, the director of the Centre for Cellular and Molecular Biology in Hyderabad, one of the labs working to sequence virus samples in India, said this variant appears to be more infectious, but it isn’t likely to cause more deaths.

Also, the AstraZeneca vaccine and another from India’s Bharat Biotech International Ltd. have been shown to be effective against it in preliminary data, he said. India’s health ministry hasn’t confirmed if this variant is more transmissible, and a spokesperson for the federal health ministry could not be immediately reached.

And at the rate infections are occurring in India, B.1.617 won’t be the only or last variant of concern out of India’s second wave.

“I fear there may be more trouble coming,” said William Haseltine, a former Harvard Medical School professor and HIV researcher who now chairs think tank Access Health International. “There are already second and possibly third generation variant of the B.1.617 circulating in India. These may be more dangerous than is the B.1.617 variant itself.”

India’s second wave is certainly more destructive. Hospitals and crematoriums are cracking under pressure, while Indians are begging on social media for everything from oxygen cylinders to drugs. Almost 3,000 people are dying every day, with experts saying that figure likely underplays the real toll. The daily death rate is almost double what it was at the height of the first wave, stoking speculation the new variant, or other mutations, are to blame. Brazil, another developing country that has struggled to ramp up vaccines, suffered from a virus strain that’s said to be responsible for a much higher Covid death rate.

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