Now that we understand the basics regarding NSAIDs, let's dive into a few specific drugs from this class. First up, aspirin. This drug has been around for centuries, but now with a modern understanding of chemistry and biochemistry, we are able to understand its precise structure and mechanism of action. Aspirin is unique among NSAIDs because it covalently alters a serine residue in the active site of cyclooxygenase enzymes, thereby rendering the enzyme permanently incapable of producing prostaglandins. This is what leads to aspirin's anti-inflammatory effects. Let's get a closer look at this activity now.
Script by Chris Hofmann
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