Cationic polymers such as polyethylenimine and DEAE-dextran are used to form complexes with nucleic acid and transfect cells via endocytosis. Some polymers have been developed to form micelles; Altogen Biosystems developed a proprietary biodegradable polymer-based transfection reagent for in vivo use that results in efficient and minimally toxic delivery of DNA/RNA material to the lung, liver, kidney and spleen via a single i.v. injection that results in sustainable knockdown or overexpressions. This product has been tested in mice using systemic intravenous as well as direct intratumoral injections. More information about this product can be found at:
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