/vɪˈsɪsɪtjuːd,vʌɪˈsɪsɪtjuːd/
noun
noun: vicissitude; plural noun: vicissitudes
1.
a change of circumstances or fortune, typically one that is unwelcome or unpleasant.
"her husband's sharp vicissitudes of fortune"
synonyms: change, alteration, alternation, transformation, metamorphosis, transmutation, mutation, modification, transition, development, shift, switch, turn; More
reversal, reverse, downturn;
inconstancy, instability, uncertainty, unpredictability, chanciness, fickleness, variability, changeability, fluctuation, vacillation;
ups and downs
"he maintains his sunny disposition despite life's vicissitudes"
2.
literary
alternation between opposite or contrasting things.
"the vicissitude of the seasons"
