Building on his video 'Pattern separation in the hippocampus', here Craig Stark offers a mechanistic account for the memory loss that is typically seen in neurologically healthy aging. It’s a fine example of how basic-science research – including computational modeling, rodent neurophysiology, and human neuroimaging – can be marshaled to address a question with broad societal implications.
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Relevant papers:
Yassa, M. A., Muftuler, L. T., & Stark, C. E. (2010). Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo. Proceedings of the National Academy of Sciences, 107(28), 12687-12691.
Yassa, M. A., Mattfeld, A. T., Stark, S. M., & Stark, C. E. (2011). Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proceedings of the National Academy of Sciences, 108(21), 8873-8878.
