Welcome to Science With Tal!

In this video, we will cover the main steps of the vesicle cycle. The video will cover neurotransmitter uptake, the reserve pool, docking and priming to membrane, exocytosis and endocytosis. The video will also cover the kiss and run and kiss and stay pathways.

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Timestamps

0:00 Introduction
0:16 Brief historical perspective
0:52 Neurotransmitter uptake
1:41 Reserve pool
2:06 Docking & priming to membrane
3:43 Fusion (exocytosis)
5:00 Complex disassembly (SNARE dissociation)
5:38 Clathrin-mediated endocytosis
6:33 Reversible fusion pore mechanisms (Kiss and run/stay)
7:40 Summary of each step and each protein involved
8:16 Conclusion

Resources used

Here is a list of the resources that I’ve used to produce this video. (Author: title resource)

- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Robertson, J. David: Some Features of the Ultrastructure of Reptilian
Skeletal Muscle
- Heuser, J E et al. : Synaptic vesicle exocytosis captured by quick freezing
and correlated with quantal transmitter release
- Heuser, J E and T S Reese: Evidence for recycling of synaptic vesicle
membrane during transmitter release at the frog neuromuscular junction
- Llinás, R and Y Yarom: Properties and distribution of ionic
conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro
- Katz, B, and R Miledi: A study of synaptic transmission in the
absence of nerve impulses
- BOYD, I A,and A R MARTIN: The end-plate potential in mammalian
muscle
- DEL CASTILLO, J, and B KATZ: Quantal components of the end-plate potential

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

Video credits

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - jay ([ Ссылка ])

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