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Here, we have discussed about *Pharmaceutics CH-19.2 | Flocculated & Deflocculated Suspension And Formulation Of Suspension* and prepared a best content for you so watch the complete video until the end and read the description below.

*Formulation Of Suspension
a.Wetting agent:
B. Flocculating agent:
C. Thickening agent:
D. Preservative:
E. Buffer:
F. Coloring agent:
G. Flavoring agent:
H. Sweetening agent:
I. Solvents
J. Osmotic agents
K. Humectants
L. Anti-Oxidants

A.Wetting agent / Surfactants:
These are the substances which reduce the interfacial tension between the solid particles and liquid medium, thus producing a suspension of required quality.
Ex. Alcohol, Tragacanth mucilage, glycerin, sodium alginate or Bentonite dispersion and Polysorbate in oral and Parenteral suspensions.

Surfactants
Generally, we use non-ionic surfactants
Polysorbate 80 is most widely used due to its following advantages
It is non-ionic so no change in pH of medium
No toxicity. Safe for internal use.

B. Flocculating agent:
The solid particles are well dispersed in dispersion medium i.e., vehicle.
The dispersion can be improved by adding a surfactant or protective colloid which acts as flocculating agent.
E.g., sodium lauryl sulphate, tweens, spans, carbowaxes and electrolytes. 

*Structured Vehicle
Structured vehicles called also thickening or suspending agents.
They are aqueous solutions of natural and synthetic gums.
It is applicable only to deflocculated suspensions. E.g. methyl cellulose, sodium carboxy methyl cellulose, acacia, gelatin and tragacanth.
These structured vehicles entrapped the particle and reduces the sedimentation of particles.
Structured vehicle is not useful for Parenteral suspension because they may create problem in syringe ability due to high viscosity. 

C. Thickening agent:
Polysaccharides:
Natural polysaccharide:
Gum acacia, Tragacanth, Starch, Sodium alginate:
b. Semi synthetic:
Methyl cellulose, Sodium carboxy methyl cellulose, Microcrystalline cellulose:
2. Inorganic agents:
Clay, Aluminum hydroxide
3. Synthetic:
Carbomer, Colloidal silicon dioxide.

D. Preservative:
Suitable preservative is needed to preserve suspensions against bacterial growth.
Preservatives selected should be effective against a wide range of microorganism.
Benzoic acid, sodium benzoate, methyl paraben and propyl paraben are commonly used as a preservative in suspensions.

E. Buffer:
Buffer are added to resist the change in pH. Ex. Sodium citrate


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