If you ever wondered what weapon uses Tactical Nuke ammo, here is the answer.
Tactical Nuke ammo is for Nooka Zuka rocket launcher that can be found on eastern plains part of the map. It's by far the best Rocket Launcher in wasteland 3. Most damage and huge area of effect.
Tactical nuke's are rare to find so use only when there is no other option to win those fights.
Wasteland 3 - Nooka Zuka Location - Best Rocket Launcher in the game - Tactical Nuke ammo

Following the critically acclaimed 2014 Game of the Year winner Wasteland 2, the RPG series that pioneered the post-apocalyptic genre in video games returns with Wasteland 3.

In Wasteland 3 you take command of a squad of Desert Rangers, lawmen and women in a post-nuclear world, trying to rebuild society from the ashes. More than a century after the bombs fell, you’re fighting a losing battle to keep your beloved Arizona alive. Then the self-proclaimed Patriarch of Colorado radios, promising aid if you'll do a job he can only entrust to an outsider—rescue his land from the ambitions of his three bloodthirsty children.

You’re dispatched on a desperate quest from the scorching deserts to the snowy mountains to start from scratch, building a new base, finding a snow-worthy vehicle, training new recruits, and fighting your way through hostile frozen wastes. All the while, you'll have to decide who to trust in this land torn apart by corruption, intrigue, warring factions, crazed cultists, cutthroat gangs, and bitter sibling rivalries. Build a reputation for yourself by making decisions that will profoundly impact Colorado, its inhabitants and the story you experience. Will you be Colorado’s savior or its worst nightmare?

Wasteland 3 is a squad-based RPG from inXile entertainment, featuring challenging tactical turn-based combat and a deep, reactive story full of twists, turns, and brutal ethical decisions that will keep you hooked whether you’re a Wasteland veteran or new to the series. Create a squad of up to six Rangers and customize them with perks and abilities geared to your playstyle. You even get your own battle truck, which you can upgrade into a hardened war beast, bristling with weapons, to help mow down your enemies.

The developers describe the content like this:

Wasteland 3 is a mature game that regularly depicts violence and gore through combat, strong language, and adult situations.

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