In this Research Spotlight episode, Dr. Sebastian Peil (alumnus of Fürstner group) joins us to share his work on hydrogenative C-H insertion reactions.
Key reference:
J. Am. Chem. Soc. 2022, 144, 4158 – 4167.
[ Ссылка ]
Other references (in order of appearance):
M. Leutzsch, L. M. Wolf, P- Gupta, M. Fuchs, W. Thiel, C. Farès, A. Fürstner, Angew. Chem. Int. Ed. 2015, 54, 12431 – 12436; S. Peil, A. Guthertz, T. Biberger, A. Fürstner, Angew. Chem. Int. Ed. 2019, 8851 – 8856; S. Peil, G. Bistoni, R. Goddard, A. Fürstner, J. Am. Chem. Soc. 2020, 18541 – 18553.
S. Peil, G. Bistoni, R. Goddard, A. Fürstner, J. Am. Chem. Soc. 2020, 18541 – 18553.
For CH Insertion via Carbene Alkyne Metathesis see: F. Cambeiro, S. López, J. A. Varela, C. Saá, Angew. Chem. Int. Ed. 2012, 723 - 727.
For the interpretation of temperature dependent KIEs see: H. Kwart, Acc. Chem. Res. 1982, 15, 401 – 408.
Dealkenylative Coupling: S.-C. Chen, Q. Zhu, Y. Cao, C. Li, Y. Guo, L. Kong, J. Che, Z. Guo, H. Chen, N. Zhang, X. Fang, J.-T. Lu, T. Luo, J. Am. Chem. Soc. 2021, 143, 14046 – 14052; Hydrodealkenylation: A. J. Smaligo, M. Swain, J. C. Quintana, M. F. Tan, D. A. Kim, O. Kwon, Science 2019, 364, 681 – 685.
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