The effects of Nicotinamide mononucleotide (NMN) supplementation observed in mice have sparked interest in the potential benefits it may offer to human health, particularly in the realms of cerebrovascular and cognitive health. This study was performed on old mice given a supplement called Nicotinamide mononucleotide (NMN). This supplement was found to reverse some age-related issues in the blood vessels of the brain, and increase the communication between brain activity and blood flow, known as neurovascular coupling (NVC). NMN also restored levels of a molecule called NAD+ which is crucial for energy in cells and helps the mitochondria, the powerhouses of cells, work properly. This restoration was linked to a decrease in harmful reactive oxygen species within the brain's blood vessels.
This study, and other research, suggests that increasing NAD+ levels through supplementation with NAD+ precursors like NMN could be a promising strategy for preserving cognitive ability, especially in conditions like age-related cognitive decline and Alzheimer’s disease.
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