Genetic testing for BRCA1 and BRCA2 gene mutations has not only helped science make great strides in both cancer prevention and diagnosis, but has also given insight into the genetic and historical connection between different Jewish communities. Research has shown that Jews have a significantly higher risk of being carriers of BRCA mutations. These genes help prevent tumors from forming, but if these genes are mutated, they are no longer able to suppress tumor cells, significantly increasing the risk of breast cancer and pancreatic cancer.

Though widely considered to be more prevalent amongst Ashkenazi Jews, some studies suggest that Sephardi and Mizrahi Jews may be at higher risk as well. These findings have created a priority for Jewish communities worldwide to screen for BRCA mutations. This genetic link between Jews also lends itself to the debate on Jewish identity throughout history. Whether Judaism is a religion, culture or ethnicity, shared genes provide further insight on Jews as a part of a historical people.

Chapters
00:00 Intro
00:25 What is BRCA 1 and BRCA 2?
00:58 BRCA1 and BRCA 2 heredity and breast cancer statistics
01:24 Genetic testing
01:53 Representation in Ashkenazi population
02:06 Representation in Sephardic and Mizrahi population
02:35 Representation in Latin American population in US Southwest
02:50 Theory of Crypto-Jewish BRCA gene
03:50 Shared Jewish ancestry and genetic history
05:00 Outro

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Check out @biocinematics for some amazing biology explanations!

Thanks to Michal Becker, Shira Reinhard; Dr. Rachel Michaelson Cohen from the Shaare Zedek Medical Center; and Elana Silber and Peggy Cottrell from Sharsheret for assisting us in making this video

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Image and footage credits:
– FORCE
– Atlas Obscura
– Capital FM Kenya
– Garvan Institute of Medical Research
– i24 News
– iuriimotov/Freepik.com
– Marcus Daly Memorial Hospital
– MidMichigan Health
– Sharsheret
– UC Berkeley
– VINnews
– Wellcome Images
– אחת מתשעה/One In Nine

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From ancient Jewish traditions to the modern State of Israel, we explain it all. Diving into anything and everything related to Jewish culture, history, and even religion.
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