As a result of the hostile tumor microenvironment, immune checkpoint inhibitor monotherapy has typically been ineffective in glioblastoma, which as also been regarded as immunologically cold. Stephen Joseph Bagley, MD, MSCE, Hospital of the University of Pennsylvania, Philadelphia, PA, discusses strategies to improve the efficacy of immune checkpoint inhibitors in patients with glioblastoma. By adding radiotherapy and GITR inhibition, the tumor can be primed for immunotherapy and regulatory T cell activity can be reduced. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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