Teenagers Teddy and PJ Duncan and their 10-year-old brother, Gabe, are enlisted to help raise the newest addition to their family, Charlotte (nicknamed "Charlie"), when their parents return to work. With their parents juggling full time careers, they pitch in, getting very familiar with baby formula, burps, clothes, and babysitting while navigating typical teenage life.

Each video diary ends with Teddy (or another family member, even Charlie) saying the eponymous phrase, "Good luck, Charlie".

Main Cast:
Teddy Duncan - Bridgit Mendler
Amy Duncan - Leigh-Allyn Baker
Gabe Duncan - Bradley Steven Perry
Charlie Duncan - Mia Talerico
Bob Duncan - Eric Allan Kramer
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Music: Unknown Brain - Perfect 10 (ft. Heather Sommer)
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