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A Caenorhabditis elegans Model System for Amylopathy Study - a 2 minute Preview of the Experimental Protocol

Zhibing Duan, Federico Sesti
University of Medicine and Dentistry of New Jersey, Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School;

We describe methods to study aspects of amylopathies in the worm C. elegans. We show how to construct worms expressing human Aβ42 in neurons and how to test their function in behavioral assays. We further show how to obtain primary neuronal cultures that can be used for pharmacological testing.

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