Infectious Secrets Series |Rectal Vancomycin Secret: Save Lives in Severe C. difficile Infections

Here's on another Infectious Secret about Rectal Vancomycin
📚 "When standard therapy fails, here’s a clever secret for severe C. difficile infections with ileus: rectal vancomycin enemas! 🦠 Learn how this off-label method delivers high antibiotic concentrations directly to the colon when oral vancomycin isn’t effective.

🩺 Key Highlights:

When to Use: For partial ileus, combine rectal enemas with oral vancomycin. For complete ileus, replace oral vancomycin with rectal enemas and add IV metronidazole.
How It’s Done: Use 500 mg in 100 mL normal saline (NS) retained for as long as possible and replaced every 6 hours.
Duration: Typically 10 days, but extend to 14 days if the response is delayed.
Why It Works: Direct delivery to the colon bypasses systemic absorption issues.

⚠️ Caution: Reserved for non-responders and performed by experts only due to the risk of colonic perforation.

✨ Know the difference, make the impact. Stay tuned for more Infectious Secrets to sharpen your clinical skills!"

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