Understand how insertion of human familial Alzheimer's disease genes into rodents is the foundation of most models of Alzheimer's disease.
Briefly explain the process of generating genetically engineered mice.
Explain how endogenous promoter regions can be used to target gene expression to specific locations within the mouse.
Describe the APP/PS1 mouse model of Alzheimer's disease and list some of its strengths and weaknesses.
Describe the APP NL-F mouse model of Alzheimer's disease.
Explain the differences between gene insertion and knock-in mice using the APP/PS1 and APP NL-F mice as examples.
Describe the differences between using a mouse model vs. a rat model of Alzheimer's disease.
Describe how we test the memory of rodents using the Morris Water Maze and Novel Object/Smell tasks.
By the end of this video, viewers should be able to understand the basics of animal models of Alzheimer's disease, including how genetically engineered mice are generated and the use of endogenous promoter regions. They should also be familiar with two commonly used mouse models, the APP/PS1 and APP NL-F models, and their strengths and weaknesses. In addition, viewers should understand the differences between gene insertion and knock-in mice, as well as the differences between using a mouse model vs. a rat model of Alzheimer's disease. Finally, viewers should be able to describe how we test the memory of rodents using the Morris Water Maze and Novel Object/Smell tasks.

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