Is Haldol Neurotoxic?

Haloperidol is one of the most widely-used of the older "first-generation" antipsychotic medications. Some have suggested that it's a neurotoxin and should be taken off the market. But a lot of the evidence behind this claim isn't strong at all. In fact, many of the cited studies actually show that haloperidol is safe for nerve cells -- even at concentrations much higher than would ever occur in clinical practice.

In this lecture, I critique a review article that concludes that haloperidol is neurotoxic. I go through each of the cited studies and reveal how thin the evidence actually is.

I also can't help but notice that -- of all the antipsychotic medications one could focus on -- only haloperidol is singled out for this degree of scrutiny. And (I believe) it's more than just a coincidence that it's the only member of the first-generation class of medications that competes economically with the most expensive modern medicines. So I discuss in this talk the potential conflicts of interest behind the scenes of the haloperidol neurotoxicity issue.

This lecture was given at the June 9, 2020 meeting of the SZconsult learning community. Check out SZconsult.org for more information.

SZconsult is a free consultation + education service offered by Northeast Ohio Medical University. It's open to any clinician who wants to learn more about schizophrenia-spectrum illness, or who wants to tap into the collective wisdom of the learning community to find answers to clinical problems.

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